Mice Infection in Surfactant Protein C-Deficient Pseudomonas aeruginosa to Pulmonary Macrophage Dysfunction and Susceptibility
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منابع مشابه
Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection.
To determine the role of surfactant protein-A (SP-A) in host defense, the murine SP-A locus was targeted by homologous recombination to produce mice lacking SP-A. SP-A-/- and wild-type mice were infected with mucoid Pseudomonas aeruginosa by intratracheal instillation. Pulmonary bacterial loads were greater in SP-A-/- than in wild-type mice, with increased numbers of mucoid P. aeruginosa in lun...
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