Identifying Novel Drug Targets for the Treatment of Tuberous Sclerosis Complex Using High Throughput Technologies PRINCIPAL INVESTIGATOR:
نویسنده
چکیده
Visual inspection of cells is a fundamental tool fordiscovery in biological science. Modern robotic microscopes areable to capture thousands of images from massively parallelexperiments such as RNA interference (RNAi) or small-moleculescreens. Such screens also benefit from lab automation, makinglarge screens, e.g., genome-scale knockdown experiments, morefeasible and common. As such, the bottleneck in large, image-based screens has shifted to visual inspection and scoring byexperts.In this paper, we describe the methods we have developedfor automatic image cytometry. The paper demonstrates illu-mination normalization, foreground/background separation, cellsegmentation, and shows the benefits of using a large numberof individual cell measurements when exploring data from high-throughput screens.
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TITLE: Application of FDA-Approved Memantine and Newer NitroMemantine Derivatives to Treat Neurological Manifestations in Rodent Models of Tuberous Sclerosis Complex PRINCIPAL INVESTIGATOR:
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AWARD NUMBER: W81XWH-14-1-0068 TITLE: Defining Translational Reprogramming in Tuberous Sclerosis Complex PRINCIPAL INVESTIGATOR:
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Award Number: W81XWH-11-1-0252 TITLE: Role of Altered mGluR Activity in Cognitive Impairments in TSC: Implications for a Novel Method of Treatment PRINCIPAL INVESTIGATOR:
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A Patient with Tuberous Sclerosis Complex and Spinal Muscular Atrophy; A Case Report
Background Tuberous Sclerosis Complex (TSC), and Spinal Muscular Atrophy (SMA) are two inherited disorders while they are genetically independent. TSC is characterized by the formation of multiple hamartomas in nearly all organs. SMA is a destructive neurological disorder leading to progressive muscular weakness and atrophy. Case Presentation</e...
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