Emerging Therapy Critiques Blood Pressure Management in Acute Stroke Does the Scandinavian Candesartan Acute Stroke Trial (SCAST) Resolve All of the Unanswered Questions?
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چکیده
Whether raised blood pressure in patients with acute stroke should be treated is one of the major unresolved issues in acute stroke management, due mainly to a paucity of reliable data from sufficiently powered randomized controlled trials. However, the Scandinavian Candesartan Acute Stroke Trial (SCAST), recently published in The Lancet, adds important new information about the risks and benefits of treatment of poststroke hypertension.1 Else Sandset and colleagues assessed whether careful blood pressure-lowering treatment with candesartan is beneficial in a wide range of patients with acute ischemic and hemorrhagic stroke and raised blood pressure.
منابع مشابه
Blood pressure management in acute stroke: does the Scandinavian Candesartan Acute Stroke Trial (SCAST) resolve all of the unanswered questions?
Whether raised blood pressure in patients with acute stroke should be treated is one of the major unresolved issues in acute stroke management, due mainly to a paucity of reliable data from sufficiently powered randomized controlled trials. However, the Scandinavian Candesartan Acute Stroke Trial (SCAST), recently published in The Lancet, adds important new information about the risks and benef...
متن کاملLetter by Gioia et al regarding article, "Blood pressure-lowering treatment with candesartan in patients with acute hemorrhagic stroke".
BACKGROUND AND PURPOSE Early and intensive blood pressure-lowering treatment seems to be beneficial in patients with acute hemorrhagic stroke and high blood pressure. We wanted to see if similar benefits can be shown from a later and more gradual blood pressure lowering, using data from the Scandinavian Candesartan Acute Stroke Trial (SCAST). METHODS SCAST was a randomized- and placebo-contro...
متن کاملEffects of blood pressure-lowering treatment in different subtypes of acute ischemic stroke.
BACKGROUND AND PURPOSE The Scandinavian Candesartan Acute Stroke Trial (SCAST) found no benefits of blood pressure-lowering treatment with candesartan in acute stroke. We have investigated whether the effect of treatment is different in different subtypes of ischemic stroke. METHODS SCAST was a randomized- and placebo-controlled trial of candesartan in 2029 patients presenting within 30 hours...
متن کاملRelation between change in blood pressure in acute stroke and risk of early adverse events and poor outcome.
BACKGROUND AND PURPOSE The Scandinavian Candesartan Acute Stroke Trial (SCAST) found no benefits of candesartan in acute stroke. In the present analysis we aim to investigate the effect of change in blood pressure during the first 2 days of stroke on the risk of early adverse events and poor outcome. METHODS SCAST was a multicenter, randomized controlled, double-blind trial of candesartan in ...
متن کاملEffects of candesartan in acute stroke on cognitive function and quality of life: results from the Scandinavian Candesartan Acute Stroke Trial.
BACKGROUND AND PURPOSE High blood pressure is common in the acute phase of stroke and is associated with poor outcome. We examined whether blood pressure-lowering treatment with candesartan in the acute phase affects long-term cognitive function and quality of life. METHODS Scandinavian Candesartan Acute Stroke Trial was a randomized-controlled and placebo-controlled trial of candesartan in 2...
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