Ototoxic Effects of Middle Ear Gentamicin Instillation in the Chinchilla
نویسندگان
چکیده
Gentamicin sulphate is used clinically to produce vestibular organ damage in patients with intractable vertigo. The drug is given locally by middle ear instillation. In humans, gentamicin appears to have a more toxic effect on the vestibular parts of the inner ear than on the cochlea. However, cochlear effects are not insignificant and to further explore the utility of monitoring vestibular and cochlear function during treatment, we developed an animal model (chinchilla) of this procedure. We present morphological findings, comparing vestibular sensory epithelial damage (crista ampullaris and otolith organs) with cochlear damage, in both ipsilateral and contralateral inner ears. In the chinchilla, we have failed to find a differential effect where the vestibular organs are more damaged than the cochlea. Importantly, we find significant contralateral damage even with very low gentamicin regimes. We conclude that the chinchilla is an unsuitable model for gentamicin induced, selective vestibulectomy in humans.
منابع مشابه
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