Spectroscopic Investigations and DFT Calculations on 3-(Diacetylamino)-2-ethyl-3H-quinazolin-4-one
نویسندگان
چکیده
1Department of Physics, Faculty of Art & Sciences, Bozok University, 66100 Yozgat, Turkey 2Sorgun Vocational School, Bozok University, 66100 Yozgat, Turkey 3Department of Physics, Faculty of Art & Sciences, Süleyman Demirel University, 32100 Isparta, Turkey 4Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia 5School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
منابع مشابه
Synthesis, Characterization and Biological Activity of Various Substitutedquinazolinone Derivatives Containing Dopamine Moiety
A Series of 3-Substituted phenyl 2-(3,4-dihydroxyphenyl ethyl amino)-6-substituted quinazolin-4-(3H) ones (4a-4h) have been synthesized by the reaction of 3-Substituted phenyl -2-methylbromo-6-substituted quinazolin-4-(3H) ones (3a-3h) with dopamine (3,4 dihydroxy phenyl ethyl amine). The biological screening showed that compound 4f namely 3-(2-Chloro phenyl)2-(3, 4-dihydroxyphenyl ethyl amino)...
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In the present work, the quantum theoretical calculations of the molecular structure of the compound 2-(Cyclohexylamino)-2-oxo-1-(quinolin-4-yl)ethyl 4-Chlorobenzoate have been predicted using Density Functional Theory (DFT) in the gas phase. The geometry of the title structure was optimized by B3LYP/6-31+G* and HF/6-31+G* levels of theory. The theoretical 1H and 13C NMR chemical shift values o...
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New series of 2,3-disubstituted quinazolin-4(3H)one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, β-diketones, anhydrides, acrylonitrile, ethyl cinnamate,...
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The title compound, C22H16N2O2 {systematic name: 3-(4-hy-droxy-phen-yl)-2-[(E)-2-phenyl-ethen-yl]quinazolin-4(3H)-one}, consists of a substituted 2-[(E)-2-aryl-ethen-yl]-3-aryl-quinazolin-4(3H)-one skeleton. The substituents at the ethyl-ene fragment are located in trans positions. The phenyl ring is inclined to the quinazolone ring by 26.44 (19)°, while the 4-hy-droxy-phenyl ring is inclined t...
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A new series of 3-substituted (methyl, ethyl or phenyl)-3H-quinazolin-4-one derivatives (4a-l) were synthesized through condensation reaction of their potassium salts (3a-l) with methyl, ethyl and phenylisocyanate. The newly synthesized derivatives (4a-l) were evaluated for anticonvulsant activity. It was found that these compounds showed the highest anticonvulsant activity at low doses (50-100...
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