Rosuvastatin, but not Simvastatin, Provides End-Organ Protection in Stroke-Prone Rats
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چکیده
Luigi Sironi, Elisabetta Gianazza, Paolo Gelosa, Uliano Guerrini, Elena Nobili, Anita Gianella, by Antiinflammatory Effects Rosuvastatin, but not Simvastatin, Provides End-Organ Protection in Stroke-Prone Rats Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000157145.98200.55 2005;25:598-603; originally published online January 27, 2005; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/25/3/598 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2005/02/27/01.ATV.0000157145.98200.55.DC1.html Data Supplement (unedited) at:
منابع مشابه
Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects.
OBJECTIVE Brain abnormalities, preceded by a systemic inflammation, develop in spontaneously hypertensive stroke-prone rats (SHRSP). In this model, we investigated whether the hydrophilic statin, rosuvastatin, influences the development of inflammation associated with brain abnormalities. Because differences in hydrophilicity/hydrophobicity contribute to the differences in statin pharmacology, ...
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