Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ.
نویسندگان
چکیده
Poly(ethylene glycol)-peptide- and glycosaminoglycan-peptide conjugates obtained by a regio-selective amino acid protection strategy are converted into cell-instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells and dorsal root ganglia.
منابع مشابه
Modulating Biofunctional starPEG Heparin Hydrogels by Varying Size and Ratio of the Constituents
Heparin and four-armed, end-functionalized polyethylene glycol (starPEG) were recently combined in sets of covalently linked biohybrid hydrogel networks capable of directing various therapeutically relevant cell types. To extend the variability and applicability of this novel biomaterials platform, the influence of size and molar ratio of the two building blocks on the hydrogel properties was i...
متن کاملDesign, synthesis and biological evaluation of Ciprofloxacin- peptide conjugates as anticancer agents
Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...
متن کاملDesign, synthesis and biological evaluation of Ciprofloxacin- peptide conjugates as anticancer agents
Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...
متن کاملNucleic acid carriers based on precise polymer conjugates.
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure-activity relationships have constantly hampered progress in the development of nucleic acid carriers. This review focuses on the synthetic concepts for the generation of precise polymers, site-specific conjugation strategies, and multifunctional conjugates for nucleic acid transport. Dendrimers, def...
متن کاملSynthesis and Antitumor Activity of Poly(organophosphazene)/ Doxorubicin Conjugates
Doxorubicin shows a wide spectrum of activity for solid tumors such as sarcomas, adenocarcinomas and melanomas, but its strong side effects including myelosuppression, extravasation reaction and cardiotoxicity have been a serious problem.1 Polymer-anticancer drug conjugates have been studied in order to improve the side effects of the anticancer drugs. In comparison with low-molecular weight an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advanced materials
دوره 25 18 شماره
صفحات -
تاریخ انتشار 2013