Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.

The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon.

It is well known that the majority of healthy individuals exposed to Mycobacterium tuberculosis do not become clinically ill. We have previously shown that in recently exposed healthy contacts of tuberculosis (TB) patients, a strong immune response to the M. tuberculosis 6-kDa early secreted antigenic target (ESAT-6) virulence factor correlated with a higher risk of subsequent disease, although...

IL - 4 Antagonist IL - 4 Express High Levels of Th 1 Cytokines and Mycobacterium tuberculosis Infection with Healthy Individuals That Control a Latent

In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis.

RATIONALE Tuberculosis progresses despite potent Th1 responses. A putative explanation is the simultaneous presence of a subversive Th2 response. However, interpretation is confounded by interleukin 4delta2 (IL-4delta2), a splice variant and inhibitor of IL-4. OBJECTIVE To study levels of mRNA encoding IL-4 and IL-4delta2, and their relationship to treatment and clinical parameters, in cells ...

مقایسه ی سطح سرمی α-TNF، اینترلوکین-10، اینترلوکین-12 و اینترفرون گاما در بیماری های ناشی از مایکوباکتریوم های توبرکلوزیس و غیرتوبرکلوزیس

Introduction: Determination of produced cytokines, especially interleukin 10, interleukin 12, interferon gamma and TNF-α is an important tool in the review of safety responses against inducers such as illnesses. The purpose of this study was to investigate the immune system status in patients with mycobacterium infections such as tuberculosis and non-tuberculosis as compared to healthy controls...

Cytokine Production in Hymenolepis Nana Infection

Background: Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also impor-tant in some cestodes like Hymenolepis nana. Objective: To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNγ, IL-5, and IL-13 were de-termined in serum of humans ...