Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela.
نویسندگان
چکیده
We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 60 10 شماره
صفحات -
تاریخ انتشار 2016