A spin label study of the effect of chrysotile asbestos on erythrocyte membranes.
نویسندگان
چکیده
Alterations in erythrocyte membranes caused by UICC B chrysotile asbestos fibres were studied in red cell ghosts using the spin label technique. The electron paramagnetic resonance (EPR) spectra of two sulphydryl reactive spin labels and one fatty acid spin probe in erythrocyte ghosts showed membrane protein modifications but no changes in lipid fluidity caused by the haemolytic chrysotile asbestos fibres.
منابع مشابه
Interaction of erythrocyte membranes with particulates.
Chrysotile fibers promoted the fusion of human erythrocyte membranes and the hemolysis and fusion of fowl erythrocytes. Amosite and glass fibers did not show the same effect. These findings provide a model for the internalization of the fibers by animal cells.
متن کاملInteractions of chrysotile asbestos with erythrocyte membranes.
Chrysotile asbestos causes lysis of red blood cells. It has been proposed that the mechanism of hemolysis is mediated through interactions between asbestos and cell membrane glycoproteins. Our studies support this concept and the following results are reported. Electron microscopy shows that asbestos fibers distort red blood cells and bind to cell membranes which may become wrapped around the f...
متن کاملA spin label study of the effects of asbestos, quartz, and titanium dioxide dusts on the bovine erythrocyte membrane.
The effects of five UICC asbestos samples, titanium dioxide, and quartz on the bovine red cell membrane have been studied in erythrocyte ghosts by the spin labelling technique. Analysis of the electron paramagnetic resonance (EPR) spectra of two sulphydryl reactive spin labels and one fatty acid spin label in red cell ghosts showed modifications in membrane protein after asbestos treatment but ...
متن کاملInhibition by phospholipids of haemolytic action of asbestos.
Haemolysis by asbestos fibres results from an increase in membrane permeability and not from rupture of red blood cells (RBC). The effect of chrysotile asbestos on RBC is at least partly, if not completely, attributable to lipid extraction and adsorption on to the fibres. This was suggested by the hyperbolic relationship between the haemolytic activity of chrysotile and the relative concentrati...
متن کاملبررسی کانی‌شناسی آزبست در مجموعه دگرگونی تخت سلیمان در شمال شرق تکاب-NW ایران
The ultramafic rocks from the Takht-e-Soleyman metamorphic complex, in Precambrian age, are classified as serpentinized metaperidotites and serpentinites, based on degree of serpentinization. Serpentine forms more than 90 volume% of the serpentinites. On the basis of serpentine polymorphs, textural relations and micro-structure features, variety of serpentinites are determined as massive serpen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 41 1 شماره
صفحات -
تاریخ انتشار 1984