Infection in solid-organ transplant recipients.

نویسنده

  • Jay A Fishman
چکیده

Copyright © 2007 Massachusetts Medical Society. Increasingly potent immunosuppressive agents have dramatically reduced the incidence of rejection of transplanted organs while increasing patients’ susceptibility to opportunistic infections and cancer.1,2 At the same time, patterns of opportunistic infections after transplantation have been altered by routine antimicrobial prophylaxis for Pneumocystis carinii (also called P. jirovecii) and cytomegalovirus. These patterns have also been altered by the emergence of new clinical syndromes (e.g., polyomavirus type BK nephropathy) and by infections due to organisms with antimicrobial resistance. New quantitative molecular and antigen-based microbiologic assays detect previously unrecognized transplantation-associated pathogens such as lymphocytic choriomeningitis virus. These assays are used in the management of common infections such as those due to cytomegalovirus and Epstein–Barr virus (EBV). In this article, I review general concepts in the management of transplantation-associated infections and discuss recent advances and challenges.

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عنوان ژورنال:
  • The New England journal of medicine

دوره 357 25  شماره 

صفحات  -

تاریخ انتشار 2007