Pharmacodynamic interactions of omeprazole with CNS active drugs in rats.

نویسندگان

  • S M Chandrashekhar
  • A Chakrabarti
  • S K Garg
چکیده

A pharmacodynamic interactional study with omeprazole was undertaken in rats. Omeprazole (7 mg/kg, orally once daily for 14 days) significantly prolonged pentobarbitone (30 mg/kg, ip) induced hypnosis while it had no effect on haloperidol (1 mg/kg, ip) induced catalepsy or morphine (5 mg/kg, ip) induced analgesia models in rats. The study highlighted the fact that dynamic interaction with omeprazole was selective.

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عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 39 1  شماره 

صفحات  -

تاریخ انتشار 1995