Molecular Medicine Aortic Aneurysm Generation in Mice With Targeted Deletion of Integrin-Linked Kinase in Vascular Smooth Muscle Cells
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منابع مشابه
Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.
RATIONALE Integrin-linked kinase (ILK) is located at focal adhesions and links the extracellular matrix (ECM) to the actin cytoskeleton via β1- and β3-integrins. ILK plays a role in the activation of kinases including protein kinase B/Akt and glycogen synthase kinase 3β and regulates cell proliferation, motility, and survival. OBJECTIVE To determine the function of ILK in vascular smooth musc...
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