Reduced Paneth cell -defensins in ileal Crohn’s disease
نویسندگان
چکیده
*Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616; †Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226; ‡Department of Biological Sciences, California State University, Los Angeles, CA 90032; §Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; ¶Department of Internal Medicine I, Robert Bosch Hospital, 70376 Stuttgart, Germany; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, Germany; **Department of Dermatology, University of Kiel, 24105 Kiel, Germany; ††Gastrointestinal Pathology Services, AmeriPath, Inc., Department of Pathology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272; and ‡‡Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH 44195
منابع مشابه
Reduced a-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease
Revised 13 February 2008 Accepted 19 February 2008 Published Online First 27 February 2008 ABSTRACT Background and aims: Reduced ileal Paneth cell adefensin expression has been reported to be associated with Crohn’s disease, especially in patients carrying NOD2 mutations. The aim of this study was to independently assess whether NOD2, a-defensins and Crohn’s disease are linked. Methods: Using q...
متن کاملINFLAMMATORY BOWEL DISEASE NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal a-defensin expression
Background: Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of Crohn’s disease but the molecular mechanism linking this protein with the disease pathogenesis remains unclear. Human a defensins (HD-5 and HD-6) are antibiotic effector molecules predominantly expressed in Paneth cells of the ileum. Paneth cells also express NOD2. To a...
متن کاملDefensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Crohn's disease is a chronic, inflammatory disease of the intestinal mucosa. Although intestinal bacteria are implicated in disease pathogenesis, the etiology is still unclear. The main location of disease is the small intestine (ileum) and the colon. Ileal disease has been linked to a mutation in the NOD2 gene. Defensins are antimicrobial peptides and in the ileum, are mainly expressed in Pane...
متن کاملGenetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. TCF-4 (also named TCF7L2), a Wnt signalling pathway transcription factor, orchestrates Paneth cell differentiation, directly regulates the expression of HD-5 and -6, and was previously associated with the decrease of these antimicrobial peptides in a su...
متن کاملReduced Paneth cell alpha-defensins in ileal Crohn's disease.
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins HD5 and HD6. We tested the hypothesis that reduced ...
متن کاملBacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal Paneth cell α-defensins.
Paneth cell α-defensins are antimicrobial peptides involved in the control of the intestinal microbiota and immunological homeostasis. In mice, they are encoded by multiple, highly homologous genes (Defa). The transcriptional activity of ileal Defa genes was studied in response to pharmacological and genetic perturbations of the intestinal environment of C57BL/6 mice. Defa gene transcription wa...
متن کامل