Acceleration of the Development of Leukemia and Induction of Tumors in Akr Mice by Neonatal Injection of 20-methylcholanthrene.
نویسنده
چکیده
A single subcutaneous injection of 20-methylcholanthrene into newborn AKR mice less than 24 hours old resulted in the acceleration of the development of lymphocytic leukemia, and induction of subcutaneous sarcomas and multiple-lung adenomas. Morphological descriptions of the respective tumors were given. It is suggested that the lungs of newborn mice of strain AKR may prove to be a sensitive organ to evaluate carcinogenicity of certain carcinogenic compounds. ∗PMID: 14078637 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Med. Okayama 17. 51-61 (1963) ACCELERATION OF THE DEVELOPMENT OF LEUKEMIA AND INDUCTION OF TUMORS IN AKR MICE BY NEONATAL INJECTION OF 20·METHYLCHOLANTHRENE
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ورودعنوان ژورنال:
- Acta medicinae Okayama
دوره 17 شماره
صفحات -
تاریخ انتشار 1963