A new itch to scratch for TSLP.
نویسندگان
چکیده
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD. A paper in Cell transforms the understanding of the functional repertoire of TSLP in general and in AD in particular showing that TSLP can directly stimulate sensory neurons and provoke itch.
منابع مشابه
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one in ten people. Patients suffering from severe AD eventually progress to develop asthma and allergic rhinitis, in a process known as the "atopic march." Signaling between epithelial cells and innate immune cells via the cytokine thymic stromal lymphopoietin (TSLP) is thought to drive AD and the atopic...
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Itch is the main chief complaint in patients visiting dermatologic clinics and has the ability to deeply impair life quality. Itch results from activation of cutaneous nerve endings by noxious stimuli such as inflammatory mediators, neurotransmitters and neuropeptides, causing itch signal transduction from peripheral skin, through the spinal cord and thalamus, to the brain cortex. Primarily non...
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Intense itch and urge to scratch are the major symptoms of many chronic skin ailments, which are increasingly common. Vicious itch-scratch cycles are readily established and may diminish quality of life for those afflicted. We investigated peripheral and central processing of two types of itch sensation elicited by skin-prick tests of histamine and allergen solutions. Itch-related skin blood fl...
متن کاملگیاهان دارویی مؤثر در درمان خارش براساس منابع طب ایرانی
Itching is a mental feeling that elicits desire to scratch and results from stimulation of itch, pain or palpation receptors in the skin. In Iranian medicine, itching is referred as hekka. Several factors can cause this symptom. Various drugs are used to treat itching. They are sometimes costly and not readily available and have side effects. Given the time-consuming and cost-effective processe...
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عنوان ژورنال:
- Trends in immunology
دوره 35 2 شماره
صفحات -
تاریخ انتشار 2014