Evidence for Electrical Coupling in the SubCoeruleus (SubC) Nucleus.
نویسندگان
چکیده
SubCoeruleus (SubC) neurons, which are thought to modulate rapid-eye-movement (REM) sleep, were recorded in brain stem slices from 7- to 20-day rats and found to manifest spikelets, indicative of electrical coupling. Spikelets occurred spontaneously or could be induced by superfusion of the cholinergic agonist carbachol. Whole cell recordings revealed that carbachol induced membrane oscillations and spikelets in the theta frequency range in SubC neurons in the presence of fast synaptic blockers. Electrical coupling in neurons is mediated by the gap junction protein connexin 36 (Cx 36). We found that Cx 36 gene expression and protein in the mesopontine tegmentum decreased during development. Cx 36 protein levels specifically in the SubC decreased in concert with the developmental decrease in REM sleep. The presence of electrical coupling in the SubC introduces a novel potential mechanism of action for the regulation of sleep-wake states.
منابع مشابه
Electrotonic coupling in the nucleus SubCoeruleus. Focus on "evidence for electrical coupling in the SubCoeruleus (SubC) nucleus".
New findings by Heister et al. presented in this issue of the Journal of Neurophysiology (p. 3142–3147) suggest that neurons in the rat pontine subcoeruleus (SubC) nucleus are electrotonically coupled. Electrical neurotransmission in the CNS is frequently generated by members of the connexin (Cx) family of proteins. Heister et al. report that SubC neurons robustly express mRNA and protein for C...
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ورودعنوان ژورنال:
- Journal of neurophysiology
دوره 97 4 شماره
صفحات -
تاریخ انتشار 2007