Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany.

OBJECTIVE To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI). DESIGN Prospective controlled blinded study. SETTING Tertiary care center. PATIENT(S) A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years. MAIN OUTCOME MEASURE(S) Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4-6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children. RESULT(S) There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence. CONCLUSION(S) The ICSI children born at term develop normally, similar to SC children.