Visual Histology

factors produced by human small cell lung cancer cell lines; these factors include the bombesin-like gastrin-releasing peptide. They also discuss the development of antibodies to these growth factors, leading to clinical trials with antipeptide hormone antibodies in humans. The second half of the volume is concerned with clinical advances and issues in oncology. Steve Rosenberg reports in detail the accumulated results of his wellpublicized phase II trials of IL-2 alone and IL-2 with LAK cells in patients with metastatic cancer. A modest number of responses were seen, especially in patients with renal cell cancer and melanoma, suggesting that adoptive immunotherapy, though wrought with numerous side effects, may hold some promise of efficacy. Future gains are discussed with regard to the combination of standard chemotherapeutic drugs or tumor-directed monoclonal antibodies with LAK cells plus IL-2, as well as the recently discovered tumor-infiltrating lymphocytes (TILs), which display more specific and potent antitumor activity. Also noteworthy is an excellent review of the biology, clinical understanding, and current therapeutic options for treating CML, including bone marrow transplant and interferon. As a whole, this book accurately portrays the current state of oncology, characterized by many exciting advances in the laboratory, but few frank successes in the clinic. Many of the basic science fields reviewed in this volume, however, appear to be moving quickly toward an era of clinical relevance and expansion, and it is to be hoped that some of the novel strategies to combat cancer discussed in the basic science chapters will appear in the clinical chapters in future editions of this series. Important Advances in Oncology 1988 is an excellent source of very readable reviews in experimental cancer biology and treatment and continues to be a good resource both for clinicians and researchers involved in oncology or pharmacology, as well as for students interested in the molecular biology and pharmacology of cancer.