Is measles virus a molecular mimicry trigger of Crohn’s disease? Authorship:
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منابع مشابه
Bioinformatic and immunological analysis reveals lack of support for measles virus related mimicry in Crohn’s disease
BACKGROUND A link between measles virus and Crohn's disease (CD) has been postulated. We assessed through bioinformatic and immunological approaches whether measles is implicated in CD induction, through molecular mimicry. METHODS The BLAST2p program was used to identify amino acid sequence similarities between five measles virus and 56 intestinal proteins. Antibody responses to measles/human...
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The aetiology of Crohn’s disease is unknown. Any hypothesis must take into account the continuing increase in incidence in some countries, including the UK. The increase aVects the population from early teens, and specific comprehensive epidemiological studies in children and adolescents show a continuing rise in the rate of age and sex standardised incidence in Scotland. This suggests an envir...
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Preventive immunization has provided one of the major advances in population health during the past century. However, a surprising cultural phenomenon is the emergence of concerns about immunization safety, in part due to prominently controversial biomedical studies. One ongoing theoretical safety concern is the possibility of human molecular mimicry by measles, mumps, rubella (MMR) antigens. T...
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