IN THE SPOTLIGHT G34, Another Connection between MYCN and a Pediatric Tumor
نویسندگان
چکیده
Authors’ Affi liation: University of California San Francisco, San Francisco, California Corresponding Author: William A. Weiss, University of California San Francisco, 1450 Third Street, Room 277, MC 0520, San Francisco, CA 94158-9001. Phone: 415-502-1694; Fax: 415-476-0133; E-mail: [email protected] doi: 10.1158/2159-8290.CD-13-0126 ©2013 American Association for Cancer Research. IN THE SPOTLIGHT G34, Another Connection between MYCN and a Pediatric Tumor Miller Huang and William A. Weiss Summary: Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery , Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis. Cancer Discov; 3(5); 484–6. ©2013 AACR.
منابع مشابه
G34, another connection between MYCN and a pediatric tumor.
Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
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