mTORC1: Turning Off Is Just as Important as Turning On
نویسندگان
چکیده
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
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ورودعنوان ژورنال:
- Cell
دوره 156 شماره
صفحات -
تاریخ انتشار 2014