An enantioselective Brønsted acid catalyzed enamine Mannich reaction.
نویسندگان
چکیده
An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
منابع مشابه
Bifunctional Iminophosphorane Organocatalysts for Enantioselective Synthesis: Application to the Ketimine Nitro-Mannich Reaction
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2007