1468Detection of High CSF Levels of (1 → 3)-Beta-D-Glucan in Cryptococcal Meningitis
نویسندگان
چکیده
Cryptococcal Meningitis Joshua Rhein, MD; Nathan Bahr, MD; Bozena Morawski, MPH; Charlotte Schutz; Malcolm Finkelman, PhD; David Meya, MMed; Graeme Meintjes, MD; David Boulware, MD, MPH; Infectious Disease and International Medicine, University of Minnesota, Minneapolis, MN; Infectious Disease Institute, Makerere University, Kampala, Uganda; Epidemiology and Community Health, University of Minnesota, Minneapolis, MN; University of Cape Town, Cape Town, South Africa; Associates of Cape Cod, Inc., East Falmouth, MA; Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, MN
منابع مشابه
Detection of High Cerebrospinal Fluid Levels of (1→3)-β-d-Glucan in Cryptococcal Meningitis
BACKGROUND (1→3)-β-d-Glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections. However, BDG is not thought to be useful in diagnosing cryptococcosis. We evaluated the utility of BDG as an adjunct diagnostic tool for patients infected with human immunodeficiency virus (HIV) and presenting with suspected cryptococcal meningitis. METHODS The Fungitell assay was used to mea...
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Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay...
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The clinical data and cerebrospinal fluid (CSF) 14-3-3-gamma protein detection of eight adult HIV-negative cryptococcal meningitis (CM) cases were examined. The eight cases included six males and two females aged 35-70 years (mean = 49.8 years). The duration between the onset of CM symptoms and the first CSF study ranged from 1 to 60 days. Initial neuroimaging study was abnormal in 87.5% (7/8) ...
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Cryptococcal meningitis has been described in immunocompromised patients, as well as in those for whom no immune defect has been identified. GM-CSF regulates the function of phagocytes and pulmonary alveolar macrophages, critical elements in cryptococcal control. We performed clinical histories, immunological evaluation, and anticytokine autoantibody screening in four current patients with cryp...
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We studied the ability of Cryptococcus neoformans to produce the hexitol D-mannitol in vitro and in rabbits with experimental meningitis. Twelve of twelve human isolates of C. neoformans produced D-mannitol in yeast nitrogen base plus 1% glucose and released D-mannitol into the medium. In a pilot study, pooled cerebrospinal fluid (CSF) from cortisone-treated rabbits given 3 x 10(7) C. neoforman...
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