CAR's made it to the pancreas

نویسندگان

  • Markus Chmielewski
  • Amit Maliar
  • Zelig Eshhar
  • Hinrich Abken
چکیده

Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA)- and ERBB2-specific chimeric antigen receptor against pancreatic carcinoma. Targeting CD24, a putative cancer stem cell antigen expressed by a minority of carcinoma cells, was likewise effective.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Modeling and Identification Based On CAN Network Information in Iranian Cars

    Modeling and identification of the system of Iranian cars is one of the most basic needs of automotive and consumer groups and has a broad role for safe driving. It has happened with speed increasing or changing of shift gear, effects on water temperature or the car's torque has been observed, but how much and how intensely and with what algorithm this effect is identifiable, can be modeled...

متن کامل

Protective effects of rosuvastatin against hyperglycemia-induced oxidative damage in the pancreas of streptozotocin-induced diabetic rats

Introduction: According to the powerful antioxidant effects of rosuvastatin, the present study aimed to examine the protective effects of rosuvastatin against oxidative damage of diabetic pancreas by potentiation of the antioxidant capacity in streptozotocin-induced diabetic rats. Methods: Experiment was performed in four groups of male Wistar rats (n=6 in each group): normal, diabetic and ...

متن کامل

بررسی اثر روغن هسته انگور بر هیستوپاتولوژی کبد و پانکراس و لیپیدهای پلاسما در موش‌های صحرایی دیابتی شده با استرپتوزوتوسین

 Background & Aims: Diabetes Mellitus is the most prevalent endocrine diseases causing nephropathy, retinopathy, and cardiovascular complications. Dyslipidemia, acute pancreatic necrosis, and fat metabolism disorders in liver of diabetic patients have been reported. Studies suggest that grape seed oil constitute anti-oxidant activity capable of decreasing serum cholesterol as well as liver tota...

متن کامل

Solid Pseudo-Papillary Tumor of the Pancreas in a 10 year old girl

Abstract Background Solid pseudo-papillary tumor of the pancreas (SPTP) is a rare disease with a low malignant potential. Though it shows low malignant potential 10% to 15% of the cases show aggressive behavior with metastatic involvement of the liver. The symptoms include abdominal discomfort and abdominal pain. It is very rare in early years of age. This is the case of a 10 year old girl wi...

متن کامل

Mechanical Diagnosis Using Classi cation: A Brake Diagnostic System

In this paper, we present a system to perform automated mechanical diagnosis of a car's brake system. The diagnostic process is performed by using the Generic Tasks of Hierarchcial Classiication and Routine Recognition. A classiication hierarchy is used to represent the possible malfunctions of a car's brake system. The two Generic Tasks are used to traverse the malfunction hierarchy in an atte...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2012