3 renal adaptation to chronic metabolic acidosis
نویسندگان
چکیده
Department of Cellular and Molecular Pathology, German Cancer Research Center, D-69120 Heidelberg, Germany; Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, CH-8057 Zurich, Switzerland; Lipid Pathobiochemistry Group, Department of Cellular and Molecular Pathology, German Cancer Research Center, D-69120 Heidelberg, Germany; Institute of Instrumental Analytics and Bioanalytics, Department of Biotechnology, University of Applied Sciences, D-68163 Mannheim, Germany; Center for Applied Biomedical Mass Spectrometry; and Hopital Tenon, Unité Mixte de Recherche S 702, Institut National de la Santé et de la Recherche Médicale/University of Paris 6, 75020 Paris, France Q:6
منابع مشابه
The mechanism of the increase in renal ammoniagenesis in the rat with acute metabolic acidosis.
Chronic metabolic acidosis causes several biochemical changes in the rat kidney: perhaps the most prominent of these is the increase in ammonia production from glutamine and the increase in activity of phosphate-dependent glutaminase [ 11. The changes with acute acidosis are less clear and although there is an early increase in total renal production of ammonia [2] no enzymatic change has been ...
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Objective(s)Cardiovascular disease causes a major clinical problem in patients with end stage renal disease. Since metabolic acidosis is very common in patients with end stage renal disease, we aimed to investigate the effect of experimentally-induced metabolic acidosis on serum lipid profile and aortic fatty streak (FS) formation in normal and high-cholesterol fed rabbits.Materials and Methods...
متن کاملRegulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats.
During chronic metabolic acidosis, renal glutamine utilization increases markedly. We studied the expression of the system N1 (SN1) amino acid transporter in the kidney during chronic ammonium chloride acidosis in rats. Acidosis caused a 10-fold increase in whole kidney SN1 mRNA level and a 100-fold increase in the cortex. Acidosis increased Na(+)-dependent glutamine uptake into basolateral and...
متن کاملEffects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man.
1. Whole-body intracellular pH (pHi) was measured by the 14C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis, twelve normal subjects with chronic acidosis and in fifteen patients with chronic renal insufficiency and acidosis. 2. The change in pHi per unit change in ext...
متن کاملMetabolic acidosis does not contribute to chronic renal injury in the rat.
1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested that this contributes to disease progression. This study assessed (i) whether prolonged acidosis causes chronic renal injury in the normal kidney an...
متن کاملEffects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man.
1. Arterial concentration and arterial-venous differences of glutamine across the kidney, forearm, hepato-splanchnic bed and brain were measured in patients with chronic renal insufficiency and in patients with normally functioning kidneys before and during chronic ammonium chloride acidosis. 2. In chronic renal insufficiency and in chronic metabolic acidosis there is a rise in glutamine releas...
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