Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8'-hydroxylase CYP707A.
نویسندگان
چکیده
We enlarged the uniconazole (UNI) molecule to find a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase, and synthesized various UNI derivatives that were substituted with hydrophilic and hydrophobic groups at the 4-chlorine of the phenyl group of UNI using click chemistry. Considering its potency in ABA 8'-hydroxylase inhibition, its small effect on seedling growth, and its ease of application, UT4, the UNI derivative containing the C4 alkyltriazole, was the best candidate for a highly selective inhibitor of ABA 8'-hydroxylase.
منابع مشابه
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 19 19 شماره
صفحات -
تاریخ انتشار 2009