Direct catalytic cross-coupling of alkenyllithium compounds.
نویسندگان
چکیده
A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions. In addition (1-ethoxyvinyl)lithium can be efficiently converted into substituted vinyl ethers which, after hydrolysis, give readily access to the corresponding methyl ketones in a one pot procedure.
منابع مشابه
Direct catalytic cross-coupling of alkenyllithium compounds† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03117b
A catalytic method for the direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions. In addition (1-ethoxyvinyl) lithium can be efficiently converted into substituted vinyl ethers which, afte...
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ورودعنوان ژورنال:
- Chemical science
دوره 6 2 شماره
صفحات -
تاریخ انتشار 2015