Localized lipoatrophy after intramuscular amikacin.

Case 2: A 6-year-old boy presented with nonprogressive localized depression in the left gluteal region, noticed two months ago. He had febrile urinary tract infection four months back (two months prior to the gluteal depression), for which he received multiple intramuscular amikacin injections over seven days, with most of the injections administered in the left gluteal region. No other parenteral medication was given. There was no history of pain, redness or swelling at the site after the course of injections. He never received any other intragluteal injections. On examination, a Sir, Localized acquired lipoatrophies constitute a poorly defined group of diseases clinically characterized by focal loss of fat. Many cases may be idiopathic, characterized by loss of adipose tissue without antecedent clinical or histologic inflammation.[1] Lipoatrophy may also occur as a consequence of inflammatory diseases and repeated trauma such as drug injections. Drugs that have been implicated in the pathogenesis of lipoatrophy are insulin, penicillin, and corticosteroids.[1-3] We report two cases of acquired localized lipoatrophy after multiple intramuscular injections of amikacin, which have not been reported in the literature yet. A detailed history and examination did not reveal any antecedent cause of lipoatrophy in both cases.