Ion Mobility Mass Spectrometry
نویسندگان
چکیده
for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but this could change as automated sample processing is developed. Increasing use of coupled techniques such as GC-GC, liquid chromatography-GC, and supercritical Suid chromatography-GC for the separation of complex mixtures will give resolution unachievable by single column operation. Columns with immobilized phases of a wider range of selectivity than currently exist will be developed. New sorbent (PLOT) columns and hybrid columns with low loadings of liquid phases, special application phases for separating enantiomers and isomers, and columns better able to withstand aqueous samples can be expected.
منابع مشابه
Hybrid ion mobility and mass spectrometry as a separation tool.
Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) has seen spectacular growth over the last two decades. Increasing IMS sensitivity and capacity with improvements in MS instrumentation have driven this growth. As a result, a diverse new set of techniques for separating ions by their mobility have arisen, each with characteristics that make them favorable for some experiments and...
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In this study, a rapid, simple and sensitive ion mobility spectrometry (IMS) method with corona discharge as ionization source was described for the morphine determination in human urine. Morphine was extracted and purified from urine samples using solid phase extraction procedure with C18 column. It can offer the clean extracts which no extra peaks were observed in IMS. Under operating experim...
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Note: Integration of trapped ion mobility spectrometry with mass spectrometry.
The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIM...
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■ CONTENTS Basic Ion Mobility Concepts 1423 Electrostatic and Electrodynamic Fields 1423 Resolving Power 1423 Ion Mobility Techniques 1424 Temporally-Dispersive Ion Mobility 1424 Drift Tube Ion Mobility Spectrometry (DTIMS) 1425 Traveling Wave Ion Mobility Spectrometry (TWIMS) 1426 Overtone Mobility Spectrometry (OMS) 1427 Confinement and Mobility-Selective Release 1428 Trapped Ion Mobility Spe...
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Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little attention has been paid for CCS calibration in negative ion mode. Here, we provide drift-tube CCS v...
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