CLEC-2 is an essential platelet activating receptor in hemostasis and thrombosis Running title: CLEC-2 in thrombosis

نویسندگان

  • Frauke May
  • Ina Hagedorn
  • Irina Pleines
  • Markus Bender
  • Timo Vögtle
  • Johannes Eble
  • Margitta Elvers
  • Bernhard Nieswandt
چکیده

Address correspondence to: Bernhard Nieswandt, PhD Chair of Vascular Medicine, Rudolf Virchow Center DFG Research Center for Experimental Biomedicine University Clinic Würzburg Zinklesweg 10 97078 Würzburg Fon: + 49 931 201 44060 Fax: + 49 931 201 48068 E-mail: [email protected] Blood First Edition Paper, prepublished online July 29, 2009; DOI 10.1182/blood-2009-05-222273

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CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis.

Damage to the integrity of the vessel wall leads to exposure of the subendothelial extracellular matrix (ECM), triggering platelet activation and aggregation. This process is essential for primary hemostasis but it may also lead to arterial thrombosis. Although the mechanisms underlying platelet activation on the ECM are well explored, it is less clear which receptors mediate cellular activatio...

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A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation.

C-type lectin-like receptor 2 (CLEC-2) is an essential platelet-activating receptor in hemostasis and thrombosis that is activated by the snake venom rhodocytin. We present here a differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation. Proteome analysis was based on 2D-DIGE, phosphotyrosine immunoprecipita...

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Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.

OBJECTIVE Platelet inhibition is a major strategy to prevent acute ischemic cardiovascular and cerebrovascular events, which may, however, be associated with an increased bleeding risk. The (hem)immunoreceptor tyrosine activation motif-bearing platelet receptors, glycoprotein VI (GPVI) and C-type lectin-like receptor 2 (CLEC-2), might be promising antithrombotic targets because they can be depl...

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T. K., Hughan, S. C., Pearce, A. C., Laing, G. D., T...

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New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2

Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent years. A large body of evidence now exists which suggests that platelets also play a key role in inflammation, immunity, malignancy, and furthermore in organ development and regeneration, such...

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تاریخ انتشار 2009