Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma
نویسندگان
چکیده
O. viverrini is a human liver fluke and mainly endemic in the Lower Mekong Basin, including Thailand, Lao PDR, Vietnam and Cambodia. The correlation of the high prevalence of O. viverrini infection with the high incidence of cholangiocarcinoma (CCA) in endemic areas has suggested the definitive relationship between them. Serious O. viverrini infection in endemic area plus the lack of CCA early diagnostic techniques and poor prognosis put the millions of people at the risk of CCA. Moreover, as the second most common primary liver cancer in the non-endemic area of O. viverrini, the incidence and mortality of CCA are markedly increasing in recent decades. An unexpected scenario was reported in 2012 that the mortality of CCA of the workers in one printing company in Japan was about 2900 times higher compared with that in the normal population.
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