Synthesis of reaction-ready 6,6'-biindole and 6,6'-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation.
نویسندگان
چکیده
The first synthesis of a 6,6'-biindole and 6,6'-biisatin scaffold is reported with the penultimate step being the formation of the di-heterocyclic ring by Pd(II)-catalysed intramolecular C-H functionalisation and Sandmeyer cyclisation, respectively.
منابع مشابه
The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy.
A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structur...
متن کاملThe total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra, and crystallographic data. CCDC 1431476. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc04399a Click here for additional data file. Click here for additional data file.
A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a coppercatalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structura...
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عنوان ژورنال:
- Chemical communications
دوره 46 23 شماره
صفحات -
تاریخ انتشار 2010