Immune Reactions against the Rabbit Myxoma Virus
نویسندگان
چکیده
The rabbit myxomatosis is caused by a Leporipoxvirus from the Poxviridae family. Extremely virulent strains kill the animals and no immunological reactions can be proved. Surviving individuals gain adaptive immunity that protects them from reinfection. In time virus is naturally attenuated and the resistance in the population is increased. There is not enough research about Tand B-lymphocyte immune reactions to the virus. This article deals with the scientific experience in the field of antibodies and their different protective effect. The authors have tried to analyze the data about the suppressive effects of the virus. Some of the virus proteins have also immunomodulatory activity. The molecular aspects of virulence and the oncolytic effects of myxoma virus are described. The future of myxoma virus research is directed towards its use as a part of anticancer therapy and the selection of rabbit breeds with higher antivirus resistance.
منابع مشابه
Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein.
Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with ...
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