Kaposi varicelliform eruption in a patient with epidermolysis bullosa simplex generalized severe

EB: epidermolysis bullosa HSV: herpes simplex virus INTRODUCTION Inherited epidermolysis bullosa (EB) are genodermatoses characterized by the formation of blisters after minor trauma. There are 4 major types of inherited EB: EB simplex, junctional EB, dystrophic EB, and Kindler syndrome. Classification is performed according to the mode of inheritance, the phenotype, the level of skin cleavage found by immunohistochemical analysis, and the type of mutation. EB simplex generalized severe, which was named Dowling-Meara EB, is the most serious form of EB simplex. The first lesions occur at birth as superficial arciform blistering over the entire body surface, typically after trauma or heat exposure. Oral lesions can also occur. The clinical manifestations are worse in childhood and decrease in adulthood. Onychodystrophy is often associated with the disease, and keratoderma of the palms and soles can appear after the age of 6. This rare genodermatosis is characterized by autosomal dominant transmission. Complications may involve the gastrointestinal tract, with consequences for growth and nutrition, and the ocular, genitourinary, and respiratory tracts. Skin complications include pruritus and superinfection. Bacterial and viral infections are frequently reported. Nevertheless, to our knowledge, no case of Kaposi varicelliform eruption in the context of EB has been published. Kaposi varicelliform eruption is a diffuse herpes simplex virus (HSV) infection of preexisting skin lesions. The most common association is with atopic dermatitis. This is a serious