Neurobiology of Disease Phosphoinositide-3-Kinase Activation Controls Synaptogenesis and Spinogenesis in Hippocampal Neurons
نویسندگان
چکیده
Germán Cuesto,1,2 Lilian Enriquez-Barreto,1 Cristina Caramés,2 Marta Cantarero,2 Xavier Gasull,2 Carmen Sandi,3 Alberto Ferrús,4 Ángel Acebes,4 and Miguel Morales1 1Structural Synaptic Plasticity Lab, Department of Neurodegenerative Diseases, Centro de Investigación Biomédica de la Rioja, La Rioja 26006, Spain, 2Neurophysiology Lab, Department of Physiology, Medical School, University of Barcelona, Barcelona 08036, Spain, 3Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015 Switzerland, and 4Department of Cellular, Molecular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, Madrid 28002, Spain
منابع مشابه
Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons.
The possibility of changing the number of synapses may be an important asset in the treatment of neurological diseases. In this context, the synaptogenic role of the phosphoinositide-3-kinase (PI3K) signaling cascade has been previously demonstrated in Drosophila. This study shows that treatment with a PI3K-activating transduction peptide is able to promote synaptogenesis and spinogenesis in pr...
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