Portable, On-Demand Biomolecular Manufacturing
نویسندگان
چکیده
Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeutic proteins, and other commodities. However, the need for specialized equipment and refrigeration for production and distribution poses a challenge for the delivery of these technologies to the field and to low-resource areas. Here, we present a portable platform that provides the means for on-site, on-demand manufacturing of therapeutics and biomolecules. This flexible system is based on reaction pellets composed of freeze-dried, cell-free transcription and translation machinery, which can be easily hydrated and utilized for biosynthesis through the addition of DNA encoding the desired output. We demonstrate this approach with the manufacture and functional validation of antimicrobial peptides and vaccines and present combinatorial methods for the production of antibody conjugates and small molecules. This synthetic biology platform resolves important practical limitations in the production and distribution of therapeutics and molecular tools, both to the developed and developing world.
منابع مشابه
Evaluation of portable Raman spectrometer with 1064 nm excitation for geological and forensic applications.
The development of miniaturized Raman instrumentation is in demand for applications relevant to forensic, pharmaceutical and art analyses, as well as geosciences, and planetary exploration. In this study we report on evaluation of a portable dispersive Raman spectrometer equipped with 1064 nm laser excitation. Selected samples from geological, geobiological and forensic areas of interest have b...
متن کاملDesign and fabrication of portable motion recorder: comparing lumbar kinematics in workers with and without low back pain in assembly line of a car manufacturing industry
Introduction: Workers in car manufacturing industry are at risk of a high prevalence of musculoskeletal disorders, especially low back pain. Therefore, in the present study aimed to design and fabricate a portable device to evaluate the low back kinematics and to compare these variables in workers with and without low back pain (LBP) in assembly lines of an automotive industry. Material and Me...
متن کاملFactor Analysis of Energy Demand in Iran's Manufacturing Industries with Emphasis on Energy Intensive Sectors
Examining the factors affecting changes in energy demand can help economic policymakers to adopt energy saving approaches. One method of examining these factors is factor analysis of energy demand. Given the high share of industry, especially energy-intensive industries in Iran's energy consumption, the purpose of this article is to analyse the factors affecting changes in energy consumption in...
متن کاملA Novel Portable Scissors-Type Fruit Picking Device
At present, the fruit picking in most countries still largely relies on manual operation. Manual fruit picking can protect the fruits from damage during the operation process. However, it is time-consuming and labor-intensive, and poses a potential safety risk to the workers while working at heights not reachable. Therefore, a variety of fruit picking machines and platforms have been developed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 167 شماره
صفحات -
تاریخ انتشار 2016