Modeling and simulation of receptor-toxin-antibody interaction
نویسنده
چکیده
This paper describes a simple, kinetic model of the effect of an antibody on the binding of a toxin to its receptor. This model has been used to evaluate the contributions of antibody affinity and concentration to reduction in complex formation and enable prediction of the antibody kinetic constants and concentration required to provide a specified degree of protection. An expression for determining equilibrium time for the system has also been derived. Based on the proposed model we analytically calculated the relative reduction in toxin-receptor complex formation a variety of input parameters (kinetic constants and concentrations). Our analytical results were validated by numerical simulations, using the COPASI tool. Experimental validation of the model may provide a useful tool for in vitro selection of potentially therapeutic and prophylactic antibodies for progression to in vivo evaluation.
منابع مشابه
پیشبینی برهمکنش بین ترکیبات موجود در برهموم زنبور عسل و بخش آنتیژن حفاظتکننده موجود در سم سیاه زخم با استفاده از نرمافزارهای بیوانفورماتیک
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