Ignacio Flores , Epidermal Stem Cell Behavior Effects of Telomerase and Telomere Length on

نویسنده

  • Ignacio Flores
چکیده

. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of February 3, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/309/5738/1253 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1115025/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/309/5738/1253#related-content http://www.sciencemag.org/cgi/content/full/309/5738/1253#otherarticles , 8 of which can be accessed for free: cites 28 articles This article 89 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/309/5738/1253#otherarticles 31 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/medicine Medicine, Diseases : subject collections This article appears in the following

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres

Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomerase shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a direct impact of telomere length and telomerase activity on stem cell biology. We recently found that short telomeres impair the ...

متن کامل

A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres

Telomere maintenance is essential to ensure proper size and function of organs with a high turnover. In particular, a dwarf phenotype as well as phenotypes associated to premature loss of tissue regeneration, including the skin (hair loss, hair graying, decreased wound healing), are found in mice deficient for telomerase, the enzyme responsible for maintaining telomere length. Coincidental with...

متن کامل

P-86: Evaluation of Telomere Length, Telomerase and Telomeric Repeat Containing RNA (TERRA) Expression Levels in Cumulus Cells of PCOS Patients

Background Polycystic ovary syndrome (PCOS) is one of the reasons of infertility in women with chronic anovulation. Ovulation process is tightly regulated by molecular mechanisms controlling proliferation/differentiation of cells. Telomeres, TTAGGG tandem repeats, are transcribed into a non coding RNA, named TERRA. Recent studies suggest that TERRA sustain several important functions at chromos...

متن کامل

The effect of high intensity interval training on telomere length and telomerase activity in non-athlete young men

Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. ...

متن کامل

Quantitative theory of telomere length regulation and cellular senescence.

In normal somatic cells, telomere length shortens with each cell replication. This progressive shortening is associated with cellular senescence and apoptosis. Germ cells, stem cells, and the majority of cancer cells express telomerase, an enzyme that extends telomere length and, when expressed at sufficient levels, can immortalize or extend the life span of a cell line. It is believed that tel...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010