miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner.
نویسنده
چکیده
A recent study identified genetic variations within the miRNA response elements of miRNA target genes (miRSNP) that can affect the base paring between miRNAs and their targets, and hence alter miRNA-target interactions. The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1058205 SNP T-allele.
منابع مشابه
IN THE SPOTLIGHT miRSNP - Based Approach Identifi es a miRNA That Regulates Prostate - Specifi c Antigen in an Allele - Specifi c Manner
1 Department of Laboratory Medicine, and the Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada. 2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Corresponding Author: George M. Yousef, St. Michael’s Hospital, 209 Victoria Street, Toronto, ON M5B1T8, Canada. ...
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ورودعنوان ژورنال:
- Cancer discovery
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2015