Truncated Channels by the Reinitiation of Translation
نویسندگان
چکیده
3 Matthew R. Stump, Qiuming Gong and Zhengfeng Zhou* 4 5 Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon 97239 6 7 Running Title: Truncation of hERG PAS domain associated with LQT2 mutations 8 9 *Corresponding Author: Dr. Zhengfeng Zhou 10 Knight Cardiovascular Institute 11 Oregon Health & Science University 12 3181 SW Sam Jackson Park Road 13 Portland, OR 97239 14 Phone: (503) 494-2713 15 Fax: (503) 418-9381 16 Email: [email protected] 17 18 19 20 Articles in PresS. Am J Physiol Heart Circ Physiol (August 30, 2013). doi:10.1152/ajpheart.00304.2013
منابع مشابه
LQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.
The human ether-a-go-go-related gene (hERG) encodes a voltage-activated K(+) channel that contributes to the repolarization of the cardiac action potential. Long QT syndrome type 2 (LQT2) is an autosomal dominant disorder caused by mutations in hERG, and patients with LQT2 are susceptible to severe ventricular arrhythmias. We have previously shown that nonsense and frameshift LQT2 mutations cau...
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