Op-brai130214 3176..3186

Daphnia magna bacterial infection in genotype and maternal environment on different stages of Disentangling the influence of parasite genotype, host

References http://rspb.royalsocietypublishing.org/content/279/1741/3176.full.html#related-urls Article cited in: http://rspb.royalsocietypublishing.org/content/279/1741/3176.full.html#ref-list-1 This article cites 42 articles, 11 of which can be accessed free Subject collections (17 articles) microbiology • (183 articles) health and disease and epidemiology • (1287 articles) evolution • Arti...

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.

The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs were determined in cation-adjusted Mueller-Hinton broth (MHB) and in Chelex-treated, dialyzed MHB (CDMHB). Spontaneous resistance was assessed at 2×...

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Hessian recovery for finite element methods

In this article, we propose and analyze an effective Hessian recovery strategy for the Lagrangian finite element method of arbitrary order. We prove that the proposed Hessian recovery method preserves polynomials of degree k + 1 on general unstructured meshes and superconverges at a rate of O(hk) on mildly structured meshes. In addition, the method is proved to be ultraconvergent (two orders hi...

Kinetic and structural changes in H smt PheRS, induced by pathogenic mutations in human FARS 2

Mutations in the mitochondrial aminoacyl-tRNA synthetases (mtaaRSs) can cause profound clinical presentations, and have manifested as diseases with very selective tissue specificity. To date most of the mtaaRS mutations could be phenotypically recognized, such that clinicians could identify the affected mtaaRS from the symptoms alone. Among the recently reported pathogenic variants are point mu...