Soluble Guanylate Cyclase a1–Deficient Mice: a novel murine model for Primary Open Angle Glaucoma
نویسنده
چکیده
Emmanuel S. Buys1*, Yu-Chieh Ko2,3, Clemens Alt4, Sarah R. Hayton1, Alexander Jones2, Laurel T. Tainsh1, Ruiyi Ren5, Andrea Giani6, Maeva Clerte’7, Emma Abernathy2, Robert E. T. Tainsh1, Dong-Jin Oh6, Rajeev Malhotra7, Pankaj Arora7, Nadine de Waard2, Binglan Yu1, Raphael Turcotte4,8, Daniel Nathan1, Marielle Scherrer-Crosbie7, Stephanie J. Loomis6, Jae H. Kang9, Charles P. Lin4, Haiyan Gong5, Douglas J. Rhee6, Peter Brouckaert10, Janey L. Wiggs6, Meredith S. Gregory2,6, Louis R. Pasquale2,6,9, Kenneth D. Bloch1,7, Bruce R. Ksander2,6
منابع مشابه
Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the α1 subunit of the nitric oxide receptor soluble guanylate cyclase represent a novel and translatable animal model of POAG, characterized by thinning of the retinal nerve fiber layer and loss of optic ner...
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Background Primary open angle glaucoma (POAG) is a progressive eye disease that leads to blindness due to the irreversible loss of retinal ganglion cells and degeneration of the optic nerve (ON). As of yet, there is no cure for glaucoma. Although available therapies delay disease progression, they offer incomplete protection. Elevated intraocular pressure (IOP) is an important risk factor for P...
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Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis. Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in ...
متن کاملGenetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase a1 deficient mice
Background We previously reported that male mice deficient in the a1 subunit of the NO receptor soluble guanylate cyclase (sGCa1 -/mice), an important nitric oxide (NO) receptor, are hypertensive [1]. The phenotype depends on the genetic background: sGCa1 -/mice on a 129S6 (S6) background (sGCa1 ) but not on a C57BL/6 (B6) background (sGCa1 ) develop hypertension [2]. These findings suggest tha...
متن کاملGenetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase α1 deficient mice
Background We previously reported that male mice deficient in the a1 subunit of the NO receptor soluble guanylate cyclase (sGCa1 -/mice), an important nitric oxide (NO) receptor, are hypertensive [1]. The phenotype depends on the genetic background: sGCa1 -/mice on a 129S6 (S6) background (sGCa1 ) but not on a C57BL/6 (B6) background (sGCa1 ) develop hypertension [2]. These findings suggest tha...
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