Prospective Phase II Trial of intravesical Taxotere in conjunction with Bacillus Calmette Guérin-Interferon Alpha IIB in the Treatment of Recurrent Superficial Transitional Cell Carcinoma of the Urinary Bladder
نویسنده
چکیده
This is a phase II study to determine the efficacy and toxicity of intravesical Taxotere in conjunction with Bacillus Calmette-Guérin (BCG)-Interferon Alpha IIB (IFN) in the treatment of recurrent superficial transitional cell carcinoma (TCC) of the urinary bladder. The purpose of this trial is to see whether the addition of intravesical Taxotere to BCG-INF increases disease-free survival by a clinically important parameter for patients with refractory TCC. As many patients failing intravesical treatment are left with cystectomy as their only option, there is a need for the development of alternative nonsurgical options for refractory TCC.
منابع مشابه
Bacillus Calmette-Guérin immunotherapy in the treatment of superficial bladder cancer
Bladder cancer is the second most common cancer in the urinary tract and the most frequent histological type is transitional cell carcinoma (TCC). Approximately 70% of these cancers are superficial (no evidence of muscle invasion) in situ (Tis), Ta and T1 carcinomas. The biological behavior of these tumors varies from slight recurrence tendency to a high degree of recurrence and progression. Al...
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