Response of plasma aldosterone to postural change, diuretica, angiotensin II, sodium restriction or loading and prostaglandin.

This paper shows the result of plasma aldosterone which was measured by radioimmunoassay method using aldosterone-3-carboxymethoxamineBSA or aldosterone-hemisuccinate-BSA. Normal control value at recumbency or upright, primary aldosteronism, uremia, essential hypertension and miscellaneous diseases were examined. By diuretica, plasma aldosterone of normal volunteer was increased but that of patients with edema was decreased temporarily. The response of plasma aldosterone in edematous patient to the constant infusion of Angiotensin II, was stronger than that of normal volunteer. But primary aldosteronism with adenoma showed the sequentially decreased plasma aldosterone by the constant infusion of Angiotension II. Some of the primary aldosteronism showed the normal response to the sodium loading and restriction. By the pressure dose Prostaglandin A2 or E1 infusion, the plasma aldosterone showed a tendency to increase.