Last Word on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing.

نویسندگان

  • David Wang
  • Robert J Thomas
  • Brendon J Yee
  • Ronald R Grunstein
چکیده

David Wang, Robert J. Thomas, Brendon J. Yee, and Ronald R. Grunstein Sleep & Circadian Group, Woolcock Institute of Medical Research, The University of Sydney, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, Australia; NHMRC Centre of Research Excellence in Sleep Medicine-NeuroSleep, Australia; Central Clinical School, The University of Sydney, Sydney, Australia; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

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منابع مشابه

Commentaries on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing.

TO THE EDITOR: Wang et al. (4) argue that when explaining neurocognitive dysfunction in OSA, there has been insufficient attention given to hypercapnia, which may be more important than hypoxia. Although we agree with the former point, we believe that it may be premature to conclude the latter. We agree with Wang and colleagues that the evidence for a relationship between hypoxia and cognition ...

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Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing.

1Sleep & Circadian Group, Woolcock Institute of Medical Research, The University of Sydney, Australia. 6 2Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney Local Health District. 7 3NHMRC Centre of Research Excellence in Sleep Medicine NeuroSleep, Australia. 4Central Clinical 8 School, The University of Sydney. 5Beth Israel Deaconess Medical Center, Harvard Medi...

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Comparing the effect of hypercapnia and hypoxia on the electroencephalogram during wakefulness.

OBJECTIVE Hypoxia has been postulated as a key mechanism for neurocognitive impairment in sleep-disordered breathing. However, the effect of hypoxia on the electroencephalogram (EEG) is not clear. METHODS We examined quantitative EEG recordings from 20 normal volunteers under three 5-min ventilatory control protocols: progressive hypercapnia with iso-hyperoxia (pO2=150mmHg) (Protocol 1), prog...

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Sleep Disordered Breathing and the Pathogenesis of Atrial Fibrillation.

This review illustrates the importance of sleep disordered breathing in evolution and progression of atrial fibrillation. While in early years associations were mainly attributed to the impact of hypoxemia and hypertension, nowadays multiple, additional pathways have been investigated or are currently under investigation. Sleep disordered breathing has been shown to have a direct impact on mech...

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Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats.

Sleep-disordered breathing is associated with pulmonary hypertension and raised haematocrit. The multiple episodes of apnoea in this condition cause chronic intermittent hypoxia and hypercapnia but the effects of such blood gas changes on pulmonary pressure or haematocrit are unknown. The present investigation tests the hypothesis that chronic intermittent hypercapnic hypoxia causes increased p...

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عنوان ژورنال:
  • Journal of applied physiology

دوره 120 12  شماره 

صفحات  -

تاریخ انتشار 2016