Disease burden and the role of pharmacogenomics in African populations
نویسندگان
چکیده
Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe 3 International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Wernher and Beit Building (South), UCT Campus, Anzio Road, Observatory, 7925, Cape Town, South Africa Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa Department of Archaeology, University of Cape Town, Cape Town, Rondebosch 7701, South Africa
منابع مشابه
Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation
South Africa, like many other developing countries, stands to benefit from novel diagnostics and drugs developed by pharmacogenomics guidance due to high prevalence of disease burden in the region. This includes both communicable (e.g., HIV/AIDS and tuberculosis) and non-communicable (e.g., diabetes and cardiovascular) diseases. For example, although only 0.7% of the world's population lives in...
متن کاملBurden of Disease Attributable to Suboptimal Breastfeeding in Iran during 1990-2010; Findings from the Global Burden of Disease Study 2010
Background: This study uses data of the global burden of diseases (GBD) study 2010 to report death, disability-adjusted life year (DALYs), years of life lived with disability (YLDs) and years of life lost due to premature mortality (YLLs), attributed to suboptimal breastfeeding by age and gender during 1990 to 2010 in Iran. Materials and Methods:The GBD assessments were used, together with esti...
متن کاملPharmacogenomics of glibenclamide in patients with type 2 diabetes mellitus: A systematic review
Introduction: One of the most widely used anti-diabetic drugs is sulfonylureas, which is often used as one of the first-line drugs in the treatment of type 2 diabetes. Due to the effect of the patient's genetic structure on the drug response (personalized medicine), the identification of genetic variations not only reduces the rate of adverse drug reactions but can also predict the effectivenes...
متن کاملInfluence of History, Geography, and Economics on the Elimination of Malaria: A Perspective on Disease Persistence in Rural Areas of Zambia
The fight against malaria is currently ongoing in many countries where the disease is still endemic. The overall target is to eliminate malaria in all nations, regardless of their malaria burden, by 2030. Currently, the disease has been eliminated mainly in low-burden and unstable malaria areas globally. However, in high-burden countries, particularly in Africa, the disease is still not elimina...
متن کاملGenetic Analysis of Nigerian Indigenous Goat Populations Using Microsattelite Markers
This study was conducted to determine the genetic relationships among and population history of four Nigerian indigenous goat populations. A total of 200 goats from three breeds namely Sahel (60), Red Sokoto (60), West-African dwarf (60) and Kano Brown, a strain (20), were used for the study. Tissue samples were collected from the ear of animals using an Allflex® ear punch tissue sample collect...
متن کامل