Hemostasis, Thrombosis, and Vascular Biology
نویسندگان
چکیده
1Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston; 2Harvard–Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge; 3Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston; and 4Harvard Stem Cell Institute, Cambridge, MA
منابع مشابه
Comparison of Celox powder and conventional dressing on hemostasis of vascular access site in hemodialysis patients
Background: Common measures to stop bleeding can run the risk of clotting and thrombosis due to prolonged application of pressure. Topical homeostatic agents have an important role in decreasing time to hemostasis and consequently prevention of the complications. Aim: the aim of this study was to compare Celox powder and conventional bandage on time to hemostasis in the vascular access site i...
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Hemostasis is a tightly regulated physiological sequence of events that maintains vascular integrity and imminent blood loss after vessel injury. Platelets play a critical role in primary hemostasis and in regulation of coagulation. Under physiological conditions, hemostasis and thrombosis are in a fragile equilibrium. Uncontrolled platelet activation leads to intravascular thrombosis and organ...
متن کاملIntrinsic pathway of coagulation and arterial thrombosis.
Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that may occlude vessels (thrombosis). Many antithrombotic drugs target key elements of the plasma coagulation mechanis...
متن کاملRole of tissue factor in hemostasis, thrombosis, and vascular development.
Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. TF deficiency causes embryonic lethality in the mouse and there have been no reports of TF deficiency in humans. These results indicate that TF is essential for...
متن کاملComputational approaches to studying thrombus development.
In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of ...
متن کاملMinimal functional model of hemostasis in a biomimetic microfluidic system.
Biology is functional, and this function both inspires and puzzles. Inspiration from biology has led to the development of biomimetic systems—artificial systems that function by mimicking biology. Biomimetic systems have been successfully created in self-assembly, 2] materials, chemical synthesis, and surface chemistry. They often provide insight into the puzzles of biology, because to develop ...
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