Effect of Hemidesmus indicus leaf extract on Liver enzymes of Diabetic induced Wistar rats

Many traditional plant treatments for diabetes mellitus are used throughout the world and few of the traditional plant treatments for diabetes have been shifted scientific scrutiny. The present study aimed to study the effect of Hemidesmus indicus plant leaf extract on the liver enzymes in alloxan induced diabetic Wister rats. Hemedesmus indicus plant was successively extracted with different organic solvents (acetone and chloroform) in increasing polarity order by using Soxhlet extractor. The extract was treated in diabetic rats and observed the levels of liver enzymes Glucose-6-Phosphatase, Lactate Dehydrogenase, Hexokinase, Glucose-6-Phosphate Dehydrogenase. The enzyme concentration was compared to diabetic control and standard drug treated rats. The Glucose-6-Phosphatase, Lactate Dehydrogenase levels were decreased and Hexokinase, Glucose-6-Phosphate Dehydrogenase levels were increased in extract treated rats when compared to control rats. This study concludes that, Hemedesmus indicus made a significant effect in regulating and controlling carbohydrate metabolic enzymes such as Hexokinase, Glucose-6-phosphatase, Glucose-6-phosphatae Dehydrogenase and Lactate Dehydrogenase very effectively.