Author’s response to reviews Title: Estrogen and Soy Isoflavonoids Decrease Sensitivity of Medulloblastoma and Central Nervous System Primitive Neuroectodermal Tumor Cells to Chemotherapeutic Cytotoxicity Authors:

Title: Estrogen and Soy Isoflavonoids Decrease Sensitivity of Medulloblastoma and Central Nervous System Primitive Neuroectodermal Tumor Cells to Chemotherapeutic Cytotoxicity Authors: Scott Belcher ([email protected]) Caleb Burton ([email protected]) Clifford Cookman ([email protected]) Michelle Kirby ([email protected]) Gabriel Miranda ([email protected]) Fatima Saeed ([email protected]) Kathleen Wray ([email protected]) Version: 1 Date: 17 Mar 2017 Author’s response to reviews: The authors' response letter has also been included as a supplementary file Response to reviewer reports: Ivonne Rietjens (Reviewer 1): The manuscript by Belcher et al. describes the decrease in sensitivity of medulloblastoma and central nervous system primitive neuroextodermal tumor cells to chemotherapeutic cytotoxicity upon coexposure to estrogen and soy isoflavones.